A parasitic infection outbreak tied to lettuce served at Taco Bell locations has sickened people across five states, according to health officials investigating the contamination.

Cyclospora cayetanensis, a single-celled parasite, causes severe gastrointestinal illness in infected individuals. The parasite produces oocysts, microscopic spores that survive in contaminated produce and spread through the fecal-oral route. Symptoms include watery diarrhea, abdominal cramping, nausea, and fatigue that typically emerge one to two weeks after exposure.

Investigators traced the outbreak to lettuce distributed to Taco Bell restaurants across multiple states. Cyclospora outbreaks linked to contaminated fresh produce have occurred repeatedly over the past two decades, with previous incidents involving cilantro, raspberries, and mixed salad greens imported from endemic regions where sanitation standards differ from U.S. practices.

The parasite thrives in warm, humid climates common to Central America and South America, where agricultural workers may lack adequate sanitation facilities. Contamination typically occurs during harvest or processing when infected workers handle produce without proper hygiene measures.

The exact number of confirmed cases and affected states remains under investigation by the Centers for Disease Control and Prevention and state health departments. Taco Bell has reportedly removed the implicated lettuce from affected locations and begun working with suppliers to identify contamination sources.

Cyclospora infections respond to antibiotic treatment, typically with trimethoprim-sulfamethoxazole, though symptoms may persist for weeks without therapy. Most healthy individuals recover completely, though infections can cause severe complications in immunocompromised patients.

This outbreak highlights ongoing challenges in produce supply chain safety. Fresh vegetables undergo minimal processing compared to other foods, making contamination detection difficult. The CDC recommends that people experiencing persistent diarrhea